Taurodeoxycholic Acid-[d4] Sodium Salt Chemical Properties

storage temp. 

-20°C

solubility 

DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 3 mg/ml

form 

A crystalline solid

CAS Number Unlabeled

1180-95-6

Safety Information

WGK Germany 

WGK 2

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1

Taurodeoxycholic Acid-[d4] Sodium Salt Usage And Synthesis

Description

Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.

Uses

Taurodeoxycholic acid-d4 (sodium) is the deuterium labeled Taurodeoxycholic acid[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110

Taurodeoxycholic Acid-[d4] Sodium Salt(2410279-82-0)Related Product Information

• 2-[[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonicacid,monosodiumsalt
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• BHTRKEVKTKCXOH-GLYOETPHSA-N