Basic information Safety Supplier Related

A-18-F-NH2

Basic information Safety Supplier Related

A-18-F-NH2 Basic information

Product Name:
A-18-F-NH2
Synonyms:
  • A-18-F-NH2
  • ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE AMIDE
  • ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2
  • H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2
  • A18Famide
  • A-18-F-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2
  • Morphine Modulating Neuropeptide
  • PubChem ID: 16131005
CAS:
99588-52-0
MF:
C89H130N24O24
MW:
1920.13
Mol File:
99588-52-0.mol
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A-18-F-NH2 Chemical Properties

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-15°C
pka
4.43±0.10(Predicted)
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A-18-F-NH2 Usage And Synthesis

Uses

Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].

in vivo

Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].

Animal Model:Male CFLP mice (25-28 g)[2]
Dosage:0.25 μg/2 μL
Administration:i.c.v.; 30 min prior to the tests
Result:Decreased the immobility time and increased the climbing and swimming times.

References

[1] Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria? Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. DOI:10.1002/ar.23780
[2] Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9. DOI:10.1016/j.bbr.2014.08.007

A-18-F-NH2Supplier

GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
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Cellmano Biotech Limited
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0551-65326643 18156095617
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Nanjing Leon Biological Technology Co., Ltd.
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17705183659
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sales@njleonbiotech.com
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