O-DESMETHYLGALANTHAMINE Chemical Properties

Melting point:

227-230°C (dec.)

Boiling point:

451.9±45.0 °C(Predicted)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO: soluble

form 

A solid

pka

9.39±0.40(Predicted)

color 

White to off-white

CAS DataBase Reference

60755-80-8

O-DESMETHYLGALANTHAMINE Usage And Synthesis

Chemical Properties

Pale Yellow Powder

Uses

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Uses

A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.

Uses

Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.

Definition

ChEBI: Sanguinine is a benzazepine.

O-DESMETHYLGALANTHAMINE(60755-80-8)Related Product Information

• Galanthaminium, 7-methyl-, iodide
• Epigalanthamine N-Oxide
• AKOS 224-01
• AKOS 229-01
• Galantamine Hydrobromide
• (-)-Galanthaminyl (-)-Camphanate
• Galanthamine
• O-Desmethyl Galanthamine b-D-Glucuronide
• AKOS 228-20
• Galanthamine-N-oxide
• O-DESMETHYLGALANTHAMINE