1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Chemical Properties

Melting point:

224-226 °C (decomp)

Density 

1.353±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Sparingly), Ethanol (Slightly, Heated, Sonicated)

form 

Solid

pka

13.07±0.30(Predicted)

color 

Pale Yellow to Pale Beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

HazardClass 

IRRITANT

HS Code 

2933998090

1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Usage And Synthesis

Synthesis

GENERAL PROCEDURE: Methyl indole-3-carboxylate (5 mmol) was slowly added to hydrazine hydrate (80%, 3 mL) at room temperature. Subsequently, the reaction mixture was subjected to continuous microwave irradiation at 300 W for 5-8 min. The reaction process was monitored by thin layer chromatography (TLC). Once the reaction was complete, the mixture was cooled sufficiently to room temperature to afford the intermediate indole-3-carbohydrazide in 83-98% yield.

References

[1] Journal of Chemical Research, 2015, vol. 39, # 5, p. 296 - 299
[2] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 22 - 32
[3] Chemistry of Heterocyclic Compounds, 1982, vol. 18, # 3, p. 258 - 261
[4] Pharmazie, 2017, vol. 72, # 12, p. 707 - 713
[5] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 10, p. 1270 - 1275

1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE(15317-58-5)Related Product Information

• Indole-5-carboxaldehyde
• Indole-3-carboxaldehyde
• Indole-4-carboxaldehyde
• Indole-4-carboxylic acid
• Methyl 1H-indole-7-carboxylate
• Indole-3-glyoxylic acid
• Isatin
• Indole-6-boronic acid pinacol ester
• methyl indoline-5-carboxylate
• 6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Indole-6-carboxaldehyde
• Ethyl 3-indoleacetate
• 1H-Indole-7-carboxylic acid
• Boronic acid, B-(2,3-dihydro-1H-indol-6-yl)-
• ETHYL INDOLE-2-ACETATE
• Methyl indole-6-carboxylate
• 2,3-DIHYDROINDOL-5-OL
• INDOLIN-4-AMINE