Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Heterocyclic compound >  Pyridine compound >  Chloropyridine >  5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE

5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE

Basic information Safety Supplier Related

5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE Basic information

Product Name:
5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE
Synonyms:
  • 5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE
  • 5-Chloro-3H-imidazo[4,5-b...
  • 3H-IMidazo[4,5-b]pyridine, 5-chloro-
  • 5-chloro-1(3)H-imidazo[4,5-b]pyridine
CAS:
52090-89-8
MF:
C6H4ClN3
MW:
153.57
EINECS:
1592732-453-0
Product Categories:
  • Heterocycle-Pyridine series
Mol File:
52090-89-8.mol
More
Less

5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE Chemical Properties

Melting point:
230-232 °C
Boiling point:
262.4±50.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
7.53±0.40(Predicted)
Appearance
Light brown to khaki Solid
More
Less

Safety Information

HS Code 
2933399990
More
Less

5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE Usage And Synthesis

Synthesis

40851-95-4

122-51-0

52090-89-8

The reaction was carried out at reflux for 5 hours using 6-chloro-2,3-diaminopyridine (350 g, 2.44 mol) and triethyl orthoformate (2100 g, 14.2 mol) with the addition of p-toluenesulfonic acid monohydrate (46.5 g, 0.244 mol) as a catalyst. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction solution was concentrated and the crude product was purified by fast column chromatography to afford 5-chloro-3H-imidazo[4,5-B]pyridine (222 g, 1.45 mol) in 59% yield. The structure of the product was confirmed by nuclear magnetic resonance (NMR) spectroscopy (Figure 3).

References

[1] Helvetica Chimica Acta, 2007, vol. 90, # 6, p. 1043 - 1068
[2] Patent: CN104860943, 2017, B. Location in patent: Paragraph 0043-0045

5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINESupplier

Shangchem Co., Ltd.
Tel
+86-21-68182121
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
skychemical Co.Ltd
Tel
021-20958197 20965099
Email
sales@skychemical.com
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Email
sales@springpharma.net