Pipecuronium bromide Chemical Properties

Melting point:

262-264° (dec)

alpha 

D25 +8.1° (c = 1 in water)

storage temp. 

Store at -20°C

solubility 

DMSO, Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

52212-02-9(CAS DataBase Reference)

Safety Information

Toxicity

LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro)

MSDS

• Language:English Provider:4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide

Pipecuronium bromide Usage And Synthesis

Uses

Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery.

Definition

ChEBI: Pipecuronium bromide is a steroid ester.

brand name

Arduan (Organon).

General Description

Pipecurium bromide, 4,4 -(3 ,17 -dihydroxy-5 -androstan-2 ,16 -ylene)bis(1,1-dimeth-ylpiperazinium)dibromide diacetate (Arduan), is anondepolarizing muscle relaxant similar, both chemicallyand clinically, to pancuronium bromide. It is a long-actingdrug indicated as an adjunct to anesthesia and in patients undergoingmechanical ventilation.

Pharmacology

Pipecuronium bromide, an analogue of pancuronium, was developed in Hungary in 1980 and is marketed in Eastern Europe and the United S tates. The intubating dose is 0.07 mg kg–1. The onset time and time to recovery from block are similar to those of pancuronium, and excretion of the drug through the kidneys is significant (66%). In contrast to pancuronium, pipecuronium produces marked cardiovascular stability, having no vagolytic or sympathomimetic effects. It may therefore be useful during major surgery in patients with cardiac disease.

Pipecuronium bromide(52212-02-9)Related Product Information

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