ethyl 2-phenylpyrimidine-5-carboxylate Chemical Properties

Melting point:

93-95 °C

Boiling point:

297.7±23.0 °C(Predicted)

Density 

1.167

storage temp. 

Sealed in dry,Room Temperature

pka

-0.60±0.22(Predicted)

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

ethyl 2-phenylpyrimidine-5-carboxylate Usage And Synthesis

Synthesis

General procedure for the synthesis of ethyl 2-phenylpyrimidine-5-carboxylate from ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate: Under argon protection, anhydrous ethanol (5 mL), sodium metal (0.426 g, 18.5 mmol), benzylcarbamidine hydrochloride (2.90 g, 18.5 mmol), and diethyl 2-(ethoxymethylene)malonate were added sequentially to a round-bottomed flask ( 4.0 g, 18.5 mmol). The reaction mixture was stirred at room temperature for 9 h and subsequently poured into ice water. The precipitate was collected by filtration, washed with cold water and recrystallized in a solvent mixture of EtOH-MeOH-CHCl3 (1:1:1, 45 mL) to afford ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate (8) as a white crystalline solid in 50% yield. Compound 8 (1.2 g, 4.91 mmol) was refluxed with POCl3 (9.8 g, 63.9 mmol) at 100 °C for 1 hour. Upon completion of the reaction, the excess POCl3 was removed in vacuum, the reaction mixture was poured into ice water, filtered and washed with cold water to afford chloride 9 as a white amorphous solid in 98% yield. Subsequently, chloride 9 was stirred with zinc powder (0.176 g, 2.69 mmol, 4 eq.) in anhydrous THF (2 mL) at 60 °C for 1 h. Then 5 drops of acetic acid were added. After continued stirring at 60 °C for 23 h, the reaction mixture was cooled to room temperature, CH2Cl2 (3 mL) was added, filtered and the solvent was evaporated. Purification by silica gel column chromatography (n-hexane-EtOAc, 0.6%) afforded ethyl 2-phenylpyrimidine-5-carboxylate as a white crystalline solid in 50% yield.

References

[1] Molecules, 2013, vol. 18, # 10, p. 11683 - 11704
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983, vol. 32, # 2, p. 265 - 270
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983, # 2, p. 299 - 304

ethyl 2-phenylpyrimidine-5-carboxylate(85386-14-7)Related Product Information

• ETHYL 4-ETHOXY-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-CHLORO-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate
• ETHYL 2-PHENYL-4-(1,4-THIAZINAN-4-YL)-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-[(4-CHLOROPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-(4-METHOXYPHENOXY)-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-(2,6-DIMETHYLMORPHOLINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-(BENZYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-PHENOXY-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-MORPHOLINO-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 2-PHENYL-4-(1-PYRROLIDINYL)-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-[(3-CHLOROPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-[(3-METHYLPHENYL)SULFANYL]-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-(CYCLOHEXYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 4-(METHYLAMINO)-2-PHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 2-PHENYL-4-(PHENYLSULFANYL)-5-PYRIMIDINECARBOXYLATE
• ETHYL 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLATE
• ETHYL 2-PHENYL-4-([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)-5-PYRIMIDINECARBOXYLATE