(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Chemical Properties

Melting point:

180-230°C

alpha 

+2～+10°(D/20℃)(c=0.5,CH3OH)

Boiling point:

approximate 85℃

storage temp. 

2-8°C

solubility 

Acetonitrile (Very Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

water: 100mg/mL

Stability:

Hygroscopic; Light Sensitive;

InChI

1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1

InChIKey

IYOZTVGMEWJPKR-VOMCLLRMSA-N

SMILES

N[C@@H](C1CCC(CC1)C(=O)Nc2ccncc2)C

CAS DataBase Reference

331752-47-7

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Usage And Synthesis

Chemical Properties

White Solid

Uses

A Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Potent ROCK inhibitor

Biological Activity

Cell permeable: yes', 'Primary Target
p160 Rho-associated protein kinases (ROCK)', 'Product competes with ATP.', 'Reversible: yes', 'Target Ki: 140 nM for p160 Rho-associated protein kinases (ROCK)