Chlorthalidone Impurity G Chemical Properties

Melting point:

197-2010C

storage temp. 

-20°C Freezer

solubility 

Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White

CAS DataBase Reference

16289-13-7

Chlorthalidone Impurity G Usage And Synthesis

Description

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na⁺/Cl^- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (K_is = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (K_is = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.

Chemical Properties

White Solid

Uses

Chlorthalidone impurity. Antihypertensive agent.