Razobazam Chemical Properties

Boiling point:

706.3±60.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

pka

9.08±0.20(Predicted)

Razobazam Usage And Synthesis

Uses

Razobazam (Hoe 175) is a benzodiazepine derivative with cognitive activity. Razobazam has been shown to improve learning performance in socially deprived rats. Razobazam increased avoidance scores by 18% after training. Razobazam caused significant changes in the optical density of certain areas of the rat brain, including a 22% decrease in the lateral habenula and a 25% increase in the ventral tegmental area. Razobazam also caused a 13% increase in optical density in the prefrontal cortex of rats[1].

References

[1] Functional activity in the brain of socially deprivated rats produced by an active avoidance test after razobazam (Hoe 175) treatment: a 2-deoxyglucose study DOI:10.1016/s0163-1047(86)90401-2

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