N-Butyl-1-deoxygalactonojirimycin
N-Butyl-1-deoxygalactonojirimycin Basic information
- Product Name:
- N-Butyl-1-deoxygalactonojirimycin
- Synonyms:
-
- N-Butyl-1-deoxygalactonojirimycin
- (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol
- N-(But-1-yl)deoxygalactonojirimycin, (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)-3,4,5-trihydroxypiperidine
- (2R,3S,4R,5S)-1-Butyl-2-(hydroxyMethyl)-3,4,5-piperidinetriol
- Lucerastat
- ACT-434964
- Lucerastat (N-Butyldeoxygalactonojirimycin
- OGT-923)
- CAS:
- 141206-42-0
- MF:
- C10H21NO4
- MW:
- 219.28
- Product Categories:
-
- Glycosidase Inhibitors
- Inhibitors
- Mol File:
- 141206-42-0.mol
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N-Butyl-1-deoxygalactonojirimycin Chemical Properties
- Melting point:
- 123-124°C
- Boiling point:
- 394.7±42.0 °C(Predicted)
- Density
- 1.234±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMF: 20 mg/mL; DMSO: 30 mg/mL; Ethanol: 5 mg/mL; PBS (pH 7.2): 10 mg/mL
- form
- A crystalline solid
- pka
- 13.72±0.70(Predicted)
- color
- White to yellow
- Stability:
- Hygroscopic
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N-Butyl-1-deoxygalactonojirimycin Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
An extremely potent and selective a-D-galactosidase inhibitor. A selective inhibitior of GlcCer synthesis.
in vivo
Lucerastat (1200 mg/kg/day food admix), a GCS inhibitor, reduces Gb3 in the absence of residual-GalA activity[2].
| Animal Model: | Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender)[2]. |
| Dosage: | 1200 mg/kg/day food admix. |
| Administration: | Food admix for 20 weeks. |
| Result: | Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition. |
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