(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Chemical Properties

Boiling point:

62 °C40 mm Hg(lit.)

Density 

0.933 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.446

Flash point:

114 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

sol H2O, ether, dichloromethane.

pka

10.01±0.10(Predicted)

form 

Liquid

color 

Clear colorless to yellow

optical activity

[α]20/D +2.4°, c = 2 in benzene

Sensitive 

Air Sensitive

BRN 

3587324

CAS DataBase Reference

63126-47-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

3-9-34

HazardClass 

3

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

(S)-(+)-2-(Methoxymethyl)pyrrolidine may be used to prepare planar chiral 2-phospha[3]ferrocenophanes. It may also be used as an organocatalyst in the cross-aldol reaction of dihydroxyacetone with p-nitrobenzaldehyde to form the corresponding polyol. SMP reacts with benzoylformic acid to form (S)-N-benzoylformyl-2-(methoxymethyl)-pyrrolidine.

Definition

ChEBI: (S)-2-(methoxymethyl)pyrrolidine is a member of the class of pyrrolidines in which the only substituent is a methoxymethyl group at position 2 (the S-enantiomer0. It is a member of pyrrolidines and an ether.

Application

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE is used for chiral auxiliary; asymmetric syntheses with SMP enamines and SMP amides; asymmetric Birch reductions; asymmetric Diels-Alder reactions.

storage

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE stores at 0-4 °C under an argon atmosphere.

(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE(63126-47-6)Related Product Information

• (S)-(-)-1-AMINO-2-(METHOXYMETHYL)PYRROLIDINE
• Methyl pyrrolidine-2-carboxylate hydrochloride
• Ethyl D-(-)-pyroglutamate
• (R)-(+)-1-AMINO-2-(METHOXYMETHYL)PYRROLIDINE
• L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER
• DIHYDROERGOTAMINE MESYLATE
• Z-HYP-OME
• Methyl L-prolinate hydrochloride
• DIHYDROERGOTAMINE TARTRATE
• H-PRO-OTBU
• N-CBZ-L-PROLINE TERT-BUTYL ESTER
• (S)-(-)-2-(METHOXYMETHYL)-1-PYRROLIDINECARBOXALDEHYDE
• L-Proline benzyl ester hydrochloride
• Ethyl L-pyroglutamate
• (S,S)-(+)-2,5-BIS(METHOXYMETHYL)PYRROLIDINE
• N-METHYL-D-PROLINOL
• (R)-(+)-1-FORMYL-2-(METHOXYMETHYL)PYRROLIDINE
• (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE