BENZYLHYDRAZINE DIHYDROCHLORIDE Chemical Properties

Melting point:

143-145 °C (dec.)(lit.)

Boiling point:

149.5℃ at 95.5kPa

Density 

0.628g/cm3 at 23℃

storage temp. 

Inert atmosphere,Room Temperature

form 

Powder

color 

Slightly yellow to beige

Water Solubility 

Insoluble in water.

BRN 

3688990

InChI

InChI=1S/C7H10N2.2ClH/c8-9-6-7-4-2-1-3-5-7;;/h1-5,9H,6,8H2;2*1H

InChIKey

MSJHOJKVMMEMNX-UHFFFAOYSA-N

SMILES

N(CC1=CC=CC=C1)N.[H]Cl.[H]Cl

Dissociation constant

0.001-0.001 at 23℃

CAS DataBase Reference

20570-96-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

MU8540000

F 

10

TSCA 

Yes

HazardClass 

6.1

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29280000

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

LD50 ipr-mus: 11 mg/kg JMCMAR 18,20,75

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

BENZYLHYDRAZINE DIHYDROCHLORIDE Usage And Synthesis

Chemical Properties

slightly yellow to beige powder

Uses

Benzylhydrazine dihydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Safety Profile

Poison by intraperitoneal route.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits very toxicfumes of HCl and NOx.

Synthesis

Step 1: Tert-butyl hydrazinecarboxylate was reacted in acetone with MgSO4 and HOAc. The mixture was heated to reflux. After cooling and filtration, concentration gave a white solid (1).
Step 2: Compound (1) was dissolved in toluene with solid KOH and a phase-transfer catalyst. Benzyl bromide was added at 50??C. The temperature was then raised to 80??C. After completion, the mixture was washed, dried, and concentrated to give an oil (2f).
Step 3: 2N HCl was added to a THF solution of (2f). The mixture was heated at reflux. After concentration and drying, the dihydrochloride salt (3f) was obtained by filtration.

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