5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Chemical Properties

Boiling point:

483.7±45.0 °C(Predicted)

Density 

1.417±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 16 mg/mL at 60 °C, soluble

form 

solid

pka

3.58±0.50(Predicted)

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Usage And Synthesis

Uses

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:

• to study its effects on steroidogenic gene expression in GD15 mouse testis
• to study its effects on amyloid β production
• to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Definition

ChEBI: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine is a dialkylarylamine and a tertiary amino compound.

Biological Activity

Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo .

Biochem/physiol Actions

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE(184241-44-9)Related Product Information

• pyrimidine-4,6-diamine hydrochloride
• 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE