cannabigerolic acid Chemical Properties

Boiling point:

535.7±50.0 °C(Predicted)

Density 

1.082±0.06 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

-70°C

pka

3.42±0.43(Predicted)

form 

A neat solid

Safety Information

RIDADR 

UN 1648 3 / PGII

WGK Germany 

2

cannabigerolic acid Usage And Synthesis

Chemical Properties

white to slightly yellowish crystalline powder.

Uses

cannabigerolic acid (CBGA), a major biosynthetic precursor molecule in cannabis,exhibits divergent effects on seizures in mouse models of epilepsy. CBGA is generated from geranyl pyrophosphate and olivetolic acid by Cannabis sativaprenyltransferase (CsPT4).

Definition

ChEBI: Cannabigerolic acid is a dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant. It is a dihydroxybenzoic acid, a diterpenoid, a polyketide, a member of resorcinols and a phytocannabinoid. It is functionally related to an olivetolic acid. It is a conjugate acid of a cannabigerolate.

General Description

A non-psychoactive cannabinoid, cannabigerolic acid (CBGA), is the precursor to THCA, CBDA, and CBCA cannabinoids in Cannabis. Cannabigerolic acid reportedly has efficacy in treatment of cancer and schizophrenia. This Certified Spiking Solution^? is suitable for CBGA testing methods by HPLC, LC/MS, or GC/MS for applications in testing of Cannabis potency or impurity profiling, pharmaceutical research, and forensic analysis.

Cerilliant solution Certified Reference Materials (CRMs) of cannabinoids are supplied in a convenient, quantitative, US DEA-exempt solution format and with TK#s for Canadian customers.

References

[1] ISVETT JOSEFINA FLORES-SANCHEZ Robert V. PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants.[J]. Plant and Cell Physiology, 2008, 49 12: 1767-1782. DOI:10.1093/pcp/pcn150.
[2] LYNDSEY L. ANDERSON. Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy[J]. British Journal of Pharmacology, 2021, 178 24: 4826-4841. DOI:10.1111/bph.15661.
[3] SUZUKI S, WAKANO C, MONTEILH-ZOLLER M K, et al. Cannabigerolic Acid (CBGA) inhibits the TRPM7 ion channel through its kinase domain[J]. Function, 2023, 32 16. DOI:10.1093/function/zqad069.