vadocaine
vadocaine Basic information
- Product Name:
- vadocaine
- Synonyms:
-
- vadocaine
- N-(2-Methoxy-4,6-dimethylphenyl)-2-methyl-1-piperidinepropanamide
- OR-K-242
- Vadocaina
- Vadocainum
- CAS:
- 72005-58-4
- MF:
- C18H28N2O2
- MW:
- 304.431
- Mol File:
- 72005-58-4.mol
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vadocaine Usage And Synthesis
Originator
Vadocaine hydrochloride ,ZYF Pharm Chemical
Manufacturing Process
3-Chloro-4',6'-dimethyl-o-propananisidide was prepared by using 92.8 g (0.615 mol) 4,6-dimethyl-o-anisidine and 86 g (0.68 mol) of 3-chloropropionyl chloride, melting point 123-125°C. A mixture containing 40 g (0.165 mol) of 3-chloro-4',6'-dimethyl-o-propananisidide, 54.3 g of 3-methyl piperidine, and 330 ml of anhydrous benzene was heated for 72 hours at 65°C. 47.7 g (84.5%) of N-(2-methoxy-4,6-dimethylphenyl)-2-methyl-1- piperidinepropanamide hydrochloride was obtained by deposition of product in anhydrous acetone saturated with hydrogen chloride; melting point 192-193°C (crystallization from a mixture isopropanol-acetone).
Therapeutic Function
Antitussive, Local anesthetic