aprikalim
aprikalim Basic information
- Product Name:
- aprikalim
- Synonyms:
-
- aprikalim
- 2-(Methylaminocarbonothioyl)-2-(3-pyridinyl)-tetrahydro-2H-thiopyran 1-oxide
- N-Methyl-[tetrahydro-2-(3-pyridinyl)-2H-thiopyran]-2-carbothioamide 1-oxide
- N-Methyl[tetrahydro-2-(3-pyridyl)-2H-thiopyran]-2-carbothioamide 1-oxide
- RP-49356
- 2H-Thiopyran-2-carbothioamide, tetrahydro-N-methyl-2-(3-pyridinyl)-, 1-oxide
- N-Methyl-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide-1-oxide
- CAS:
- 89544-10-5
- MW:
- 0
- Mol File:
- 89544-10-5.mol
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aprikalim Usage And Synthesis
Uses
rel-Aprikalim (rel-RP 52891) is the relative configuration of Aprikalim (HY-121183). Aprikalim (RP 52891), a potassium channel opener (KCO), activates ATP-sensitive K+ (KATP) channels in guinea pig ventricular myocytes[1].
References
[1] D Thuringer, et al. Time-dependent fading of the activation of KATP channels, induced by aprikalim and nucleotides, in excised membrane patches from cardiac myocytes. Br J Pharmacol. 1995 May;115(1):117-27. DOI:10.1111/j.1476-5381.1995.tb16328.x