TAS 103 Chemical Properties

Melting point:

216-217 °C(Solv: ethanol (64-17-5))

Boiling point:

589.5±50.0 °C(Predicted)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

7.88±0.20(Predicted)

TAS 103 Usage And Synthesis

Uses

TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.

Biological Activity

TAS-103 is a dual DNA topoisomerase I/II (topoisomerase I/II) inhibitor for cancer research.

in vivo

target

IC 50

Topoisomerase I; Topoisomerase II

References

[1] Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II DOI:10.1016/s0006-2952(00)00402-0
[2] Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7. DOI:10.1248/bpb.25.1385
[3] Yoshida M, et al. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73(3):987-94. Epu DOI:10.1124/mol.107.043307