RA 263
RA 263 Basic information
- Product Name:
- RA 263
- Synonyms:
-
- RA 263
- 1-(2,3-Dideoxy-α-D-erythro-hexa-2-enopyranosyl)-2-nitro-1H-imidazole
- Nsc342714
- CAS:
- 82205-95-6
- MF:
- C9H11N3O5
- MW:
- 241.202
- Mol File:
- 82205-95-6.mol
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RA 263 Usage And Synthesis
Description
RA 263 is a nucleoside.
Uses
RA-263, a 2-nitroimidazole nucleoside, is an effective radiosensitizer[1][2].
in vivo
RA-263 is eliminated from plasma by a rapid alpha phase and a slower beta phase with T1/2 of 36 and 72 min, respectively[2].
References
[1] K C Agrawal, et al. Radiosensitization, pharmacokinetics, and toxicity of a 2-nitroimidazole nucleoside (RA-263). Radiat Res. 1986 Feb;105(2):227-39. PMID:3754053
[2] K C Agrawal, et al. A new potent radiosensitizer: 1-(2',3'-dideoxy-alpha-D-erythro-hex-2'-enopyranosyl)-2-nitroimidazole (RA-263). Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):403-7. DOI:10.1016/0360-3016(82)90648-4