Basic information Safety Supplier Related

LY 223982

Basic information Safety Supplier Related

LY 223982 Basic information

Product Name:
LY 223982
Synonyms:
  • LY 223982
  • 5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid
  • SYZSSLLFRVDRHL-QPJJXVBHSA-N
  • LY223982 Exclusive
  • LY223982 (Synonyms: CGS23131
  • SKF107324)
  • CGS23131
  • Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
CAS:
117423-74-2
MF:
C30H30O7
MW:
502.55
Mol File:
117423-74-2.mol
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LY 223982 Chemical Properties

Melting point:
151-152 °C
Boiling point:
753.8±60.0 °C(Predicted)
Density 
1.235±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
form 
A crystalline solid
pka
3.81±0.10(Predicted)
color 
White to off-white
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LY 223982 Usage And Synthesis

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM. LY223982 inhibits the leukotriene B4 (LTB4)-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.

Uses

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

LY 223982Supplier

ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Angel Pharmatech, Ltd.
Tel
17317130613
Email
3358272972@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com