Flavomycin Chemical Properties

Melting point:

>150° (dec.)

storage temp. 

0-6°C

solubility 

Water (Slightly)

form 

Solid

color 

Dark Brown

InChIKey

PERZMHJGZKHNGU-XIGAONJHSA-N

LogP

1.983 (est)

CAS DataBase Reference

11015-37-5

EPA Substance Registry System

Bambermycin (11015-37-5)

Safety Information

Risk Statements 

53

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

1

RTECS 

QA3020000

Toxicity

LD50 in mice (mg/kg): >2000 orally, s.c. and i.p.; 1400 i.v. (Lindner, Wallhuser)

Flavomycin Usage And Synthesis

Description

Moenomycin complex is a mixture of moenomycins A, A₁₂, C₁, C₃ and C₄, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases. The minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.

Uses

Moenomycin complex is an antibiotic and selective inhibitor of the transglycosylation step. Flavomycin (bambermycins) is an antibiotic complex obtained from Streptomyces bambergiensis containing mainly Moenomycins A and C. They are used as feed additives and growth promoters for swine, poultry and cattle.

Uses

Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b.

Definition

ChEBI: A glycophospholipid antibiotic compound with the lipid portion conjugated to a pentasaccharide fraction via a phosphate linkage.

brand name

Flavomycin (Hoechst-Roussel).

General Description

Flavophospholipol, formerly called moenomycin, was found in the culture broth of Streptomyces bambergiensis by Hoechst in 1955. This drug is called bambermycin by INN and in the United States. It shows strong activity against gram-positive bacteria and weak activity against gram-negative bacteria. Flavophospholipol has been used as a feed additive for growth promotion in poultry.

Safety Profile

Poison by intravenous route. Moderately toxic by subcutaneous route.

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