oxanosine
oxanosine Basic information
- Product Name:
- oxanosine
- Synonyms:
-
- oxanosine
- 1-Oxaguanosine
- 5-Amino-3-β-D-ribofuranosylimidazo[4,5-d][1,3]oxazin-7(3H)-one
- Imidazo[4,5-d][1,3]oxazin-7(3H)-one, 5-amino-3-β-D-ribofuranosyl-
- 5-Amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)imidazo[4,5-d][1,3]oxazin-7(3H)-one
- CAS:
- 80394-72-5
- MF:
- C10H12N4O6
- MW:
- 284.23
- Mol File:
- 80394-72-5.mol
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oxanosine Chemical Properties
- Melting point:
- 199 °C(Solv: water (7732-18-5))
- Boiling point:
- 758.1±70.0 °C(Predicted)
- Density
- 2.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 13.17±0.70(Predicted)
- form
- A solid
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oxanosine Usage And Synthesis
Uses
Oxanosine is an antibiotic isolated from the streptomyces MG265-CF34, which has anti-tumor activity. Oxanosine is also a substrate for adenosine deaminase[1][2].
References
[1] Runhan Yu, et al. Oxanosine monophosphate is a covalent inhibitor of inosine 5’-monophosphate dehydrogenase. Chem Res Toxicol. 2019 Feb 25;32(3):456–466.
[2] Papiya Majumdar, et al. Oxanosine is a substrate of adenosine deaminase. Implications for the quest for a toxicological marker for nitrosation activity. Chem Res Toxicol. 2005 Dec;18(12):1830-41. DOI:10.1021/tx050232h
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