2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol
2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol Basic information
- Product Name:
- 2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol
- Synonyms:
-
- 2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol
- 4-[(E)-2-(4-Fluorophenyl)ethenyl]-2,6-dimethylphenol
- BIL-239
- Phenol, 4-[(1E)-2-(4-fluorophenyl)ethenyl]-2,6-dimethyl-
- BI L 239,BIL 239
- CAS:
- 125722-16-9
- MF:
- C16H15FO
- MW:
- 242.29
- Mol File:
- 125722-16-9.mol
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2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol Chemical Properties
- Boiling point:
- 353.2±11.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- pka
- 10.73±0.36(Predicted)
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2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol Usage And Synthesis
Description
BI-L 239 inhibits 5-lipoxygenase products that cause bronchoconstriction.
Uses
Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC50 of 2.48 μM for inhibition of calcium ionophore-induced LTB4 generation[1].
References
[1] T C Noonan, et al. Effect of BI-L-239, A-64077 and MK-886 on leukotriene B4 synthesis by chopped guinea pig lung and on antigen-induced tracheal contraction in vitro. Prostaglandins. 1992 Dec;44(6):543-54. DOI:10.1016/0090-6980(92)90024-n
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