2'-O-methylguanosine 5'-monophosphate Chemical Properties

Density 

2.20±0.1 g/cm3(Predicted)

pka

1.86±0.10(Predicted)

2'-O-methylguanosine 5'-monophosphate Usage And Synthesis

Uses

2′-O-Methylguanosine 5′-monophosphate is the nucleotide complex group (pGm) of the ribosome and is primarily used for DNA conjugation. Today's antibodies recognize pGm, in descending order of importance, as the parent base, the methylated ribose moiety, and the phosphate group. 2′-O-Methylguanosine 5′-monophosphate can also be used to prepare RNA vaccines as a 5′-terminal nucleotide to block the RNA molecule[1][2].

Definition

ChEBI: A guanosine 5'-phosphate that is the 2'-O-methyl derivative of guanosine 5'-monophosphate.

References

[1] Vold BS. Preparation and specificity of antibodies directed toward the ribose methylated nucleotide, et al. Preparation and specificity of antibodies directed toward the ribose methylated nucleotide, 2'-O-methylguanosine 5'-monophosphate. Biochim Biophys Acta. 1981 Sep 28;655(2):265-7. DOI:10.1016/0005-2787(81)90017-4
[2] Urushibara T, et al. A modified structure at the 5'-terminus of mRNA of vaccinia virus. FEBS Lett. 1975 Jan 1;49(3):385-9. DOI:10.1016/0014-5793(75)80791-5

2'-O-methylguanosine 5'-monophosphate(24121-01-5)Related Product Information

• 2'-O-Methylguanosine