2-methylsulfonylbenzaldehyde Chemical Properties

Melting point:

98-99 °C(Solv: water (7732-18-5))

Boiling point:

385.7±34.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

solid

Appearance

White to off-white Solid

Safety Information

HS Code 

2913000090

2-methylsulfonylbenzaldehyde Usage And Synthesis

Synthesis

2-Fluorobenzaldehyde (12.4 g, 0.1 mol, 1 eq.) and methanesulfonic acid (11.2 g, 0.11 mol, 1.1 eq.) were dissolved in DMSO (75 ml) and heated to 100 °C for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into crushed ice (100 g). The resulting 2-(methylsulfonyl)benzaldehyde was collected by filtration and dried under vacuum at 45 °C for 16 h to give a yellow solid product (9.2 g, 50% yield). The product was characterized as follows: 1H NMR (300 MHz, CDCl3) δ 10.77 (1H, s, CHO), 8.18-8.16 (1H, m, ArH), 8.10-8.08 (1H, m, ArH), 7.83-7.80 (2H, m, ArH), 3.28 (3H, s, SO2CH3); LCMS (6 min) Rt = 1.93 min, (M++1) = 185.1.

References

[1] Patent: WO2004/52858, 2004, A2. Location in patent: Page 109

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