2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine Chemical Properties

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine Usage And Synthesis

Synthesis

B. Synthesis of 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepines. Lithium aluminum hydride (0.85 g, 22 mmol) was added batchwise to a solution of 3,4-dihydro-2H-benzo[f][1,4]oxazepin-5-one (1.22 g, 7.48 mmol) in tetrahydrofuran (THF, 20 mL) at 0 °C. The reaction mixture was heated to reflux for 24 h and subsequently cooled to room temperature. Water (0.85 mL), 15% aqueous sodium hydroxide solution (0.85 mL) and water (2.55 mL) were added sequentially and slowly dropwise with continuous stirring. The insoluble salt was removed by filtration and the filtrate was concentrated to give the target product 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine (0.80 g, 72% yield). Thin layer chromatography (TLC) analysis (silica gel plate, unfolding agent: ethyl acetate) showed an Rf value of 0.14. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 500 MHz, CDCl3) data: δ 7.19-7.12 (m, 2H), 7.03-6.97 (m, 2H), 4.04 (t, J = 4.5 Hz, 2H), 3.96 (s, 2H). 3.23 (t, J = 4.5 Hz, 2H), (one hydrogen signal not observed).

References

[1] Patent: US2005/38032, 2005, A1. Location in patent: Page/Page column 21
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 18, p. 3539 - 3546

2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine(17775-01-8)Related Product Information

• 1H-Benzotriazole
• Phenoxybenzamine hydrochloride
• Potassium hydrogen phthalate
• Tamoxifen
• 2-Phenoxyethanol
• 3,4-Hihydro-1,4-benzoxazepin-5(2H)-one
• 2-ETHYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-3,5-DIONE
• TIMTEC-BB SBB009858
• BENZO[F][1,4]OXAZEPINE-3,5-DIONE
• 4,5-DIHYDRO-1,4-BENZOXAZEPIN-3(2H)-ONE
• 2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine
• 1-(2,4-dihydro-1H,10H-[1,2,3]triazolo[5,1-c][1,4]benzoxazepin-10-yl)-1-methylethyl azide
• BUTTPARK 28\07-85
• BUTTPARK 28\07-82
• BUTTPARK 28\07-76
• BUTTPARK 28\07-84
• BUTTPARK 28\07-77
• BUTTPARK 38\07-42