Prinaberel Chemical Properties

Melting point:

250-252 ºC

Boiling point:

451.6±45.0 °C(Predicted)

Density 

1.413

storage temp. 

room temp

solubility 

DMSO: ≥25mg/mL

form 

powder

pka

7.50±0.20(Predicted)

color 

white to tan

InChIKey

MQIMZDXIAHJKQP-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

Prinaberel Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Uses

Prinaberel is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Biological Activity

ERB-041 is a potent, selective estrogen ERβ receptor agonist (IC50 ERβ: 5.4 nM; > 200-fold selective over ERα). ERβ plays a minor role in mediating estrogen action in the uterus, the hypothalamus/pituitary, the skeleton, and other classic estrogen target tissues. However, a clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis. There is increasing interest in finding ERβ agonists for potential use in a variety of clinical applications without triggering classic estrogenic side effects.

storage

Store at -20°C

Prinaberel(524684-52-4)Related Product Information

• 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE
• Vinyl acetate
• VINYL PROPIONATE
• N-Vinyl-2-pyrrolidone
• Silicone rubber,methyl-vinyl
• Vinyl ester resin
• Vinyl resin
• Fluorine
• 5-BENZOXAZOLOL, 2-METHYL-
• 2-(3-FLUORO-PHENYL)-BENZOOXAZOLE
• Prinaberel