2-METHYLTHIO-4-BROMOPYRIMIDINE Chemical Properties

Melting point:

30-40℃

Boiling point:

281℃

Density 

1.72

Flash point:

124℃

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

Low Melting Solid

pka

-0.76±0.20(Predicted)

color 

Pale yellow to brown

InChI

InChI=1S/C5H5BrN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3

InChIKey

TZSQAGYDWPPKPE-UHFFFAOYSA-N

SMILES

C1(SC)=NC=CC(Br)=N1

Safety Information

RIDADR 

UN1759

HazardClass 

8

HS Code 

2933599590

2-METHYLTHIO-4-BROMOPYRIMIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-methylthio-4-bromopyrimidine from 2-methylthio-4-chloropyrimidine: Bromotrimethylsilane (23 mL, 174.31 mmol) was added slowly and dropwise to an anhydrous acetonitrile (240 mL) solution of 4-chloro-2-methylthio-pyrimidine (2.9 g, 25 mmol) under argon protection. The reaction mixture was stirred in an oil bath at 40 °C for 30 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by slow addition of saturated sodium bicarbonate solution (250 mL). The aqueous phase was extracted with ethyl acetate (3 × 100 mL), and the organic phases were combined and dried over anhydrous sodium sulfate. After filtration to remove the desiccant, the organic phase was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography with the eluent dichloromethane/ethyl acetate (9:1, v/v). The target fraction was collected and the solvent was evaporated under reduced pressure to afford the target compound 2-methylthio-4-bromopyrimidine as a colorless oil in 96% yield (4.66 g). The structure of the product was confirmed by 1H NMR, 13C NMR and HPLC: 1H NMR (CDCl3) δ 2.56 (s, 3H, SCH3), 7.16 (d, 1H, J = 5.2 Hz, H-5), 8.26 (d, 1H, J = 5.2 Hz, H-6); 13C NMR (CDCl3) δ 13.5 (SCH3), 116.2 (C-5), 140.3 (C-6), 158.7 (C-4), 162.4 (C-2); HPLC Rt = 3.11 min.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 696 - 709
[2] ChemMedChem, 2016, vol. 11, # 22, p. 2522 - 2533
[3] Organic Letters, 2011, vol. 13, # 19, p. 5000 - 5003

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