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1,2,4-thiadiazole

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1,2,4-thiadiazole Basic information

Product Name:
1,2,4-thiadiazole
Synonyms:
  • 1,2,4-thiadiazole
  • Azosulfime
CAS:
288-92-6
MF:
C2H2N2S
MW:
86.12
Mol File:
288-92-6.mol
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1,2,4-thiadiazole Chemical Properties

Melting point:
-33°C
Boiling point:
121°C
Density 
1.330
refractive index 
1.5300 (estimate)
form 
liquid
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1,2,4-thiadiazole Usage And Synthesis

Description

1,2,4-Thiadiazole is a five-membered, unsaturated, conjugated heteroaromatic, consisting of one sulfur atom and two nitrogen atoms in which one is adjacent to sulfur and the other is one carbon apart in the ring. It is a π-excessive heterocycle but relatively π deficient at carbon atoms. The π electron density at C5 is lowest (0.7888) and therefore nucleophilic substitution is facile at this site.

Physical properties

The chemical shift for C3-H appeared at δ 8.66 ppm in 5-phenyl-1,2,4-thiadiazole, while the C5-H proton resonated further downfield at δ 9.9 ppm in 3-phenyl-1,2,4-thiadiazole. This indicated that C5-H is highly deshielded compared to C3-H. A comparative study of the 13C spectra of a variety of 1,2,4-thiadiazoles revealed that generally C3 resonated (δ 148–188 ppm) upfield compared to C5 (δ 161–201 ppm).

Definition

ChEBI: 1,2,4-thiadiazole is a thiadiazole.

Chemical Reactivity

Though 1,2,4-thiadiazole is a π-excessive heterocycle the electron density at both carbon atoms C3 and C5 is low but lowest at C5 due to the presence of two pyridine-like nitrogen atoms. As a result, electrophiles do not attack both the sites but are prone to nucleophilic attack. The electrophiles preferentially attack N4 compared to N2 and form quaternary salts. The parent 1,2,4-thiadiazole is sensitive to acid, alkali, oxidizing, and reducing agents.

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