BOC-PHE-D-LEU-PHE-D-LEU-PHE-OH Chemical Properties

Boiling point:

1043.2±65.0 °C(Predicted)

Density 

1.167±0.06 g/cm3(Predicted)

solubility 

Chloroform: Slightly soluble: 0.1-1 mg/ml
Methanol: Slightly soluble: 0.1-1 mg/ml

pka

3.51±0.10(Predicted)

form 

Solid

BOC-PHE-D-LEU-PHE-D-LEU-PHE-OH Usage And Synthesis

Uses

Boc-Phe-Leu-Phe-Leu-Phe, a chemotactic peptide antagonist, abolishes the FMLP-induced release of peptide leukotrienes[1].

References

[1] A M Lefer, et al. Modulation of receptor mediated leukotriene release in the perfused heart. Gen Pharmacol. 1986;17(4):437-40. DOI:10.1016/0306-3623(86)90187-4
[2] K. WENZEL‐SEIFERT R S. Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E.[J]. Journal of immunology, 1993, 150 10 1: 4591-4599. DOI: 10.4049/jimmunol.150.10.4591

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