H-MET-SER-OH Chemical Properties

Boiling point:

548.6±50.0 °C(Predicted)

Density 

1.334±0.06 g/cm3(Predicted)

storage temp. 

−20°C

pka

2.93±0.10(Predicted)

CAS DataBase Reference

14517-43-2

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

H-MET-SER-OH Usage And Synthesis

Uses

Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension[1][2].

Definition

ChEBI: Met-Ser is a dipeptide composed of L-methionine and L-serine joined by a peptide linkage. It has a role as a metabolite. It is functionally related to a L-methionine and a L-serine.

References

[1] Diana H?jmark Omkvist, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. DOI:10.1016/j.ejpb.2010.12.009
[2] Pan Wuguang, et al. Application of sulfur dipeptide for preparing antihypertensive drug or health care product. Patent WO2019006954.

H-MET-SER-OH(14517-43-2)Related Product Information

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