5-BROMO-2,1,3-BENZOTHIADIAZOLE Chemical Properties

Melting point:

55-60 °C

Boiling point:

272.2±13.0 °C(Predicted)

Density 

1.859±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

-0.73±0.36(Predicted)

Appearance

Light brown to gray Solid

CAS DataBase Reference

1753-75-9

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36-22

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2934999090

5-BROMO-2,1,3-BENZOTHIADIAZOLE Usage And Synthesis

Synthesis

Example 2 Synthesis of 5-bromo-2,1,3-benzothiadiazole: A reaction mixture was prepared by mixing 4.0 g (21 mmol) of 4-bromophthalimide, 14 mL of thionyl chloride and 0.62 mL of concentrated sulfuric acid. The mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled and subsequently slowly poured into ice water. The precipitate precipitated was collected by filtration and washed with plenty of water until the washings were neutral. Finally, the precipitate was thoroughly dried to give 4.5 g of 5-bromo-2,1,3-benzothiadiazole crude product (melting point 48 to 50 °C, yield 96.5%).

References

[1] RSC Advances, 2016, vol. 6, # 71, p. 66978 - 66989
[2] Patent: US2009/149676, 2009, A1. Location in patent: Page/Page column 5
[3] ChemMedChem, 2018, vol. 13, # 21, p. 2332 - 2348
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967, vol. 3, p. 662 - 666
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1967, vol. 3, # 5, p. 839 - 844

5-BROMO-2,1,3-BENZOTHIADIAZOLE(1753-75-9)Related Product Information

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