1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate
1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate Basic information
- Product Name:
- 1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate
- Synonyms:
-
- 2-(Diphenylphosphino)terephthalic acid 1-methyl 4-pentafluorophenyl diester 97%
- 1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate
- 2-(Diphenylphosphino)terephthalic acid 1-methyl 4-pentafluorophenyl diester
- MF:
- C27H16F5O4P
- MW:
- 530.379317
- Mol File:
- Mol File
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1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate Chemical Properties
- Melting point:
- 109-111 °C
- storage temp.
- -20°C
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1-Methyl-4-(pentafluorophenyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylate Usage And Synthesis
Uses
- Staudinger ligation reagent for the conjugation of amine and azide containing compounds or biomolecules.
- The amine functionalized molecule first reacts with the phosphine through the activated pentafluorophenyl ester.The azide-molecule is then reacted with the newly labeled phosphine to form the iminophosphorane, and the aza-ylide is subsequently captured by the methyl ester to yield the covalent conjugated product.
The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method