3-BROMO-2,5-DIAMINOPYRIDINE, 99% Chemical Properties

Melting point:

122-127 °C

Boiling point:

337.0±37.0 °C(Predicted)

Density 

1.6770 (rough estimate)

refractive index 

1.6400 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.82±0.49(Predicted)

form 

solid

Appearance

Brown to reddish brown Solid

InChIKey

YJENCMIONVUOCW-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36-43

Safety Statements 

26-36/37

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HS Code 

29333999

3-BROMO-2,5-DIAMINOPYRIDINE, 99% Usage And Synthesis

Chemical Properties

Dark brown or violet powder

Synthesis

General procedure for the synthesis of 3-bromo-2,5-diaminopyridine from 2-amino-3-bromo-5-nitropyridine: 2-amino-3-bromo-5-nitropyridine was suspended in methanol (6.0 mL) in a 30 mL flask. A solution of ammonium chloride (5.0 eq.) in water (6.0 mL) was added, followed by iron powder (5.0 eq.). The suspension was stirred and reacted at 80°C for 2 hours. Upon completion of the reaction, the mixture was filtered while hot (~50°C). The filtrate was concentrated and purified by column chromatography (using KANTO 60N silica gel with an eluent ratio of dichloromethane/methanol = 97/3 to 92/8) to afford the target product, 3-bromo-2,5-diaminopyridine solid.

References

[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3853 - 3860

3-BROMO-2,5-DIAMINOPYRIDINE, 99%(896160-69-3)Related Product Information

• Ethylenediaminetetraacetic acid
• 2,5-Diaminopyridine