(1E)-1-Cyanomethylene-2-cyclohexene-4α,6α-diol Chemical Properties

Melting point:

121-124 °C

Boiling point:

392.0±42.0 °C(Predicted)

Density 

1.449±0.06 g/cm3(Predicted)

pka

13.03±0.40(Predicted)

(1E)-1-Cyanomethylene-2-cyclohexene-4α,6α-diol Usage And Synthesis

Uses

Coclauril is an inhibitor of HBV. Coclauril inhibits HBV replication in the human hepatoblastoma cell line with an EC50 of 7.6 μg/mL[1].

References

[1] Yi XX, et al. Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza). Molecules. 2015 Aug 12;20(8):14565-75. DOI:10.3390/molecules200814565
[2] YOGO Motoi, et al. Coclauril, a nonglucosidic 2-cyclohexen-1-ylideneacetonitrile, from Cocculus lauriforius DC.. CHEMICAL & PHARMACEUTICAL BULLETIN, 38(1), 225–226.