LIXIVAPTAN
LIXIVAPTAN Basic information
- Product Name:
- LIXIVAPTAN
- Synonyms:
-
- LIXIVAPTAN
- N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
- VPA 985
- BenzaMide,N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-Methyl-
- N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide
- N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methyl-benzamide
- Lixivaptan (VPA-985)
- VPA985;LIXIVAPTAN (VPA 985)
- CAS:
- 168079-32-1
- MF:
- C27H21ClFN3O2
- MW:
- 473.93
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 168079-32-1.mol
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LIXIVAPTAN Chemical Properties
- Melting point:
- >114°C (dec.)
- Boiling point:
- 626.5±55.0 °C(Predicted)
- Density
- 1.32
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 11.86±0.70(Predicted)
- form
- powder
- color
- white to beige
- InChIKey
- PPHTXRNHTVLQED-UHFFFAOYSA-N
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LIXIVAPTAN Usage And Synthesis
Uses
Lixivaptan is a drug used in the treatment and prevention of cardiovascular diseases.
Biological Activity
Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist th at increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.
LIXIVAPTANSupplier
Dezhou LonWel Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 13761310616
- 39324283@qq.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- 021-50182298 021-50180596
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
NOTA Chemical (Shanghai) Co.,Ltd
- Tel
- 021-50189163
- sales@notachem.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
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LIXIVAPTAN(168079-32-1)Related Product Information
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- 10,11-DIHYDRO-5H-BENZO[E]PYRROLO[1,2-A][1,4]DIAZEPINE
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