3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID
3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID Basic information
- Product Name:
- 3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID
- Synonyms:
-
- 3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID
- UK-356202
- 3-[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]benzoic acid
- Benzoic acid, 3-[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]-
- CAS:
- 223671-94-1
- MF:
- C17H13ClN4O2
- MW:
- 340.76
- Mol File:
- 223671-94-1.mol
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3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID Chemical Properties
- Melting point:
- >300 °C
- Boiling point:
- 596.9±60.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- pka
- 3.99±0.10(Predicted)
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3-(4-CHLORO-1-GUANIDINOISOQUINOLIN-7-YL)BENZOIC ACID Usage And Synthesis
Description
UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.