9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Chemical Properties

Density 

2.09

storage temp. 

Sealed in dry,Room Temperature

pka

7.00±0.20(Predicted)

Safety Information

HS Code 

2933599590

9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one Usage And Synthesis

Synthesis

General procedure for the synthesis of 9-bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one from (4-bromo-2-cyanophenyl)carbamic acid ethyl ester and formylhydrazine: to a solution of (4-bromo-2-cyanophenyl)carbamic acid ethyl ester (40.4 g, 150 mmol) in N-methyl pyrrolidone (NMP, 170 mL), was added formylhydrazine ( 10.0 g, 150 mmol). The reaction mixture was stirred at 160°C for 1.5 hours in a mild nitrogen atmosphere. Upon completion of the reaction, the mixture was cooled to below 100°C and water (340 mL) was slowly added. The resulting slurry was further cooled to 25°C and stirred continuously for 15 minutes. The precipitated solid was collected by filtration and washed sequentially with water and 2-propanol. Finally, the product was dried under vacuum to afford 9-bromo-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one (32.4 g, 81% yield) as a light yellow solid. Mass spectrometry (MS) analysis result: m/e = 264.9/267.0 (M + H+).

References

[1] Patent: US2006/84642, 2006, A1. Location in patent: Page/Page column 9
[2] Patent: US2006/84801, 2006, A1. Location in patent: Page/Page column 12
[3] Patent: US2006/79507, 2006, A1. Location in patent: Page/Page column 18
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 20, p. 5940 - 5944

9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one(882517-92-2)Related Product Information

• ethyl 3-bromo-9H-benzo[f]imidazo[1,5-a][1,2,4]triazolo[4,3-d][1,4]diazepine-10-carboxylate
• 10-bromo-5H-benzo[f][1,2,4]triazolo[4,3-d][1,4]diazepin-6(7H)-one
• 4-bromo-2-(4H-1,2,4-triazol-3-yl)aniline