Ipsapirone
Ipsapirone Basic information
- Product Name:
- Ipsapirone
- Synonyms:
-
- IPSAPIRONE
- 2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE
- 1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,
- Isapirone
- 2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
- Benzeneethanamine,5-chloro-α-methyl-
- 1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide
- Ipsapirone, 10 mM in DMSO
- CAS:
- 95847-70-4
- MF:
- C19H23N5O3S
- MW:
- 401.48
- Product Categories:
-
- Serotonin receptor
- Mol File:
- 95847-70-4.mol
Ipsapirone Chemical Properties
- Melting point:
- 137-138°
- Boiling point:
- 629.8±65.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 10 mM in DMSO
- form
- Powder
- pka
- 7.69±0.10(Predicted)
- color
- White to off-white
Ipsapirone Usage And Synthesis
Uses
Anti-anxiety agent .
Uses
Ipsapirone is a selective SR-1A agonist.
Definition
ChEBI: 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one is a N-arylpiperazine.
Biological Activity
Selective 5-HT 1A receptor agonist (K i = 10 nM). Anxiolytic in vivo .
in vivo
Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1].
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1].
| Animal Model: | Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1]. |
| Dosage: | 5 and 10 mg/kg. |
| Administration: | IP 30 min before 8-OH-DPAT and 5-MeODMT injections. |
| Result: | Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.). |
IC 50
5-HT1A Receptor
storage
Room temperature
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