GTP-GAMMA-S SODIUM SALT Chemical Properties

Density 

2.68±0.1 g/cm3(Predicted)

storage temp. 

-20°C (-15°C to -25°C)

pka

0.67±0.50(Predicted)

form 

solution (deep frozen)

Safety Information

WGK Germany 

-

F 

10-21

MSDS

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GTP-GAMMA-S SODIUM SALT Usage And Synthesis

Uses

GTP-γ-S has been used:

• in G-Protein activation assay to assess the functionality of protease-activated receptor 4 (PAR4)
• in fluorimetric guanine nucleotide exchange assay of G protein alpha subunits (Gα)
• to monitor the Rac family small guanosine triphosphatase (GTPase) 2 (Rac2)-stimulated activity of phospholipase Cγ2 mutants

Definition

ChEBI: Guanosine 5'-[gamma-thio]triphosphate is a nucleoside triphosphate analogue. It is functionally related to a GTP.

General Description

Guanosine 5′-O-(3-thiotriphosphate), tetralithium salt (GTP-γ-S) is a non-hydrolysable analog of GTP. It is an inhibitor of phosphodiesterase in photoreceptors.

Biochem/physiol Actions

Guanosine 5′-O-(3-thiotriphosphate) (GTP-γ-S) activates guanine-nucleotide-binding proteins and is slowly hydrolyzed enzymatically. It inhibits guanosine triphosphatase (GTPases) more potently than guanosine triphosphate (GTP),

GTP-GAMMA-S SODIUM SALT(37589-80-3)Related Product Information

• GTP
• GTP-GAMMA-S SODIUM SALT