CUPRESSUFLAVONE TRIHYDRATE Chemical Properties

Melting point:

>400°C

Boiling point:

927.0±65.0 °C(Predicted)

Density 

1.656±0.06 g/cm3(Predicted)

pka

5.43±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

LogP

3.070 (est)

CUPRESSUFLAVONE TRIHYDRATE Usage And Synthesis

Uses

Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice[1][2][3].

Definition

ChEBI: A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, i exhibits free radical scavenging and antielastase activities.

References

[1] Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71. DOI:10.1055/s-0034-1383211
[2] Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28. DOI:10.1002/ddr.21417
[3] Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34. DOI:10.1515/intox-2015-0006

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