GGTI 298 trifluoroacetate salt hydrate Chemical Properties

Melting point:

99.5-100°C

storage temp. 

-20°C

solubility 

DMSO: >20mg/mL

form 

film &_& lyophilized

color 

colorless

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

GGTI 298 trifluoroacetate salt hydrate Usage And Synthesis

Uses

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:

• to study the anticancer effects of statins along with GGTI 298
• to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
• to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population

Biochem/physiol Actions

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

storage

Store at -20°C

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