Methyl 4-bromo-2-chloro-6-fluorobenzoate Chemical Properties

Boiling point:

299.4±40.0 °C(Predicted)

Density 

1.675±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2916399090

Methyl 4-bromo-2-chloro-6-fluorobenzoate Usage And Synthesis

Synthesis

Procedure for the synthesis of methyl 4-bromo-2-chloro-6-fluorobenzoate: to a mixture of compound 4-bromo-2-chloro-6-fluorobenzoic acid (20 g, 80 mmol) and potassium carbonate (13.2 g, 96 mmol) in N,N-dimethylformamide (200 mL) was added methylene iodide (23 g, 160 mmol). The reaction mixture was stirred at room temperature for 2 hours and subsequently poured into water (600 mL) and extracted with dichloromethane (2 x 200 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oil. Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 100:1) gave the target product methyl 4-bromo-2-chloro-6-fluorobenzoate (8 g, 49% yield, two-step reaction) as a light yellow oil.

References

[1] Patent: US2012/28952, 2012, A1. Location in patent: Page/Page column 17

Methyl 4-bromo-2-chloro-6-fluorobenzoate(1321613-02-8)Related Product Information

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