Basic information Safety Supplier Related

5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACID

Basic information Safety Supplier Related

5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACID Basic information

Product Name:
5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACID
Synonyms:
  • 5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACID
  • 5-OXOETE-GLUTATHIONE
  • FOG9
MF:
C30H47N3O9S
MW:
625.77
Mol File:
Mol File
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5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACID Usage And Synthesis

Description

FOG9 is formed through the conjugation of 5-oxoETE with glutathione in a 1,6 Michael addition at C-9. The biological activity of FOG9 has not been determined. However, FOG7, a 1,4-adduct formed within murine peritoneal macrophages, was found to be highly potent in stimulating eosinophil and neutrophil chemotaxis. FOG7 was also capable of initiating actin polymerization without elevating intracellular free calcium ion concentration within either the eosinophil neutrophils or PMNL.

5-OXO-6Z,9S-(S-GLUTATHIONYL)-11Z,14Z-EICOSATRIENOIC ACIDSupplier

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