Lithium phenyl-2,4,6-trimethylbenzoylphosphinate Chemical Properties

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

crystalline powder

color 

white to off-white

InChI

InChI=1S/C16H17O3P.Li.H/c1-11-9-12(2)15(13(3)10-11)16(17)20(18,19)14-7-5-4-6-8-14;;/h4-10H,1-3H3,(H,18,19);;

InChIKey

CVDUWYDMNPODNA-UHFFFAOYSA-N

SMILES

C(C1C(=CC(C)=CC=1C)C)(=O)P(C1C=CC=CC=1)(O)=O.[LiH]

Safety Information

WGK Germany 

WGK 3

HS Code 

2931499090

Storage Class

11 - Combustible Solids

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate Usage And Synthesis

Description

LAP (Lithium phenyl-2,4,6-trimethylbenzoylphosphinate) is a free radical initiator. The free radicals produced by LAP under bioprinting conditions are potentially cytotoxic and mutagenic. In addition, the concentration of LAP affects the mechanical strength of 3D-printed scaffolds. Generally, the concentration range of LAP used for curing is 0.05%-1%. The elastic modulus produced at a concentration of 0.1% is the highest, with enhanced mechanical properties and excellent biocompatibility.

Chemical Properties

White to off-white powder with excellent water solubility and good cellular compatibility; A blue light photoinitiator capable of rapidly initiating the curing of photosensitive hydrogel materials under blue light (wavelength 405 nm). Suitable for long-wavelength water-based photocurable coatings, water-based photocurable inks, water-based photocurable 3D printing, the curing of hydrogels containing cells, and bio-3D printing involving cells.

Uses

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

storage

Store at RT