Tert-butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate Chemical Properties

Boiling point:

426.0±40.0 °C(Predicted)

Density 

1.109±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.36±0.10(Predicted)

form 

powder

InChIKey

OWDXAWCQYCRTIR-UHFFFAOYSA-N

SMILES

O=C(N(CC1)CCC1C2=CC(CO)=CC=C2)OC(C)(C)C

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1

Tert-butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate Usage And Synthesis

Uses

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

reaction suitability

reagent type: linker

Tert-butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate(909422-39-5)Related Product Information

• 1853217-57-8
• tert-butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate
• tert-butyl 4-(3-(aminomethyl)phenyl)piperidine-1-carboxylate hydrochloride
• tert-butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
• tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate
• TERT-BUTYL 4-(4-(AMINOMETHYL)PHENYL)PIPERIDINE-1-CARBOXYLATE
• Tert-butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
• tert-butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate