6-Aminoindanone Chemical Properties

Melting point:

167-171 °C(Solv: methanol (67-56-1))

Boiling point:

330.3±31.0 °C(Predicted)

Density 

1.254±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Solution

pka

3.85±0.20(Predicted)

color 

Light brown to black

InChI

InChI=1S/C9H9NO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4,10H2

InChIKey

UOJCPAAEKXNPQT-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=CC(N)=C2)CC1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

2811

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29223900

6-Aminoindanone Usage And Synthesis

Uses

6-Amino-1-indanone is a synthetic compound belonging to the indanone class. It is an ethylene oxide synthesized via a multi-step process involving the dehydration and reductive amination of an amine. In organic chemistry, it is used as an intermediate in the synthesis of various other compounds, such as serotonin. This compound exhibits an affinity for palladium catalysts during reductive amination, which can be used for sequence optimization experiments.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 46, p. 399, 2003 DOI: 10.1021/jm020067s

Synthesis

The general procedure for the synthesis of 6-amino-1-indanone from 6-nitro-1-indanone was as follows: a mixed suspension of 6-nitroindan-1-one (10 g, 56 mmol) with 10% Pd/C catalyst (2.0 g) in methanol (200 mL) was subjected to stirring in a hydrogenation reactor for 3 hr at room temperature under a hydrogen pressure of 30 psi. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford 6-aminoindan-1-one (7.2 g, 87% yield).

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 37, p. 13052 - 13057
[2] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 396
[3] Patent: WO2007/148808, 2007, A1. Location in patent: Page/Page column 126-127
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 399 - 408
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 20, p. 5665 - 5670

6-Aminoindanone(69975-65-1)Related Product Information

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