YHO-13351 (free base)
YHO-13351 (free base) Basic information
- Product Name:
- YHO-13351 (free base)
- Synonyms:
-
- YHO13351 FREE BASE;YHO 13351 FREE BASE
- YHO-13351 (free base)
- Glycine, N,N-diethyl-, 1-[5-[(1Z)-2-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-2-thienyl]-4-piperidinyl ester
- YHO-13351 free base, 10 mM in DMSO
- CAS:
- 912288-64-3
- MF:
- C26H33N3O4S
- MW:
- 483.62
- Mol File:
- 912288-64-3.mol
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YHO-13351 (free base) Chemical Properties
- Boiling point:
- 627.1±55.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- pka
- 8.24±0.25(Predicted)
- form
- Solid
- color
- Yellow to orange
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YHO-13351 (free base) Usage And Synthesis
Uses
YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
References
[1] Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63. DOI:10.1158/1535-7163.MCT-10-0874
[2] Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86. PMID:23564776
YHO-13351 (free base)Supplier
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 0-2022843681 15618226720
- chaolaichem@foxmail.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
Musechem
- Tel
- +1-800-259-7612
- info@musechem.com
Angel Pharmatech, Ltd.
- Tel
- 17317130613
- 3358272972@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com