PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2 Chemical Properties

Density 

1.51±0.1 g/cm3(Predicted)

storage temp. 

-15°C

pka

9.82±0.15(Predicted)

PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2 Usage And Synthesis

Biological Activity

Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2 ([D-Trp6]-LH-RH-Leu-Arg-Pro-Gly-NH2) is a GnRH (gonadotropin-releasing hormone) agonist, triptorelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Triptorelin is used for the treatment of hormone-associated prostate and breast cancers, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization.

PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2(1926163-16-7)Related Product Information

• Triptorelin