AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2 Chemical Properties

Boiling point:

1250.0±65.0 °C(Predicted)

Density 

1.192±0.06 g/cm3(Predicted)

storage temp. 

−20°C

form 

powder

pka

13.33±0.46(Predicted)

color 

white

Sequence

Ac-Gln-Lys-Leu-Val-Phe-Phe-NH2

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2 Usage And Synthesis

Uses

Acetly-β Amyloid (15-20), Amide is a peptides fragment. Acetly-β Amyloid (15-20), Amide inhibits the β-sheet formation and stabilizes structure of Aβ (1–40) peptide. Acetly-β Amyloid (15-20), Amide can be used in study Alzheimer’s disease[1].

Biological Activity

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

References

[1] Lin SY, et al. Fourier transform infrared spectroscopy used to evidence the prevention of beta-sheet formation of amyloid beta(1-40) peptide by a short amyloid fragment. Int J Biol Macromol. 2003 Sep;32(3-5):173-7. DOI:10.1016/s0141-8130(03)00051-5

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2(189064-06-0)Related Product Information

• AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2
• BETA-AMYLOID (12-20)
• H2N-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH
• AMYLOID BETA-PROTEIN (6-20)
• H-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH